Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

Not Applicable

Recruiting

• Conditions: Mild Cognitive Impairment (MCI); Aging; Subjective Cognitive Decline (SCD); Healthy
• Interventions: Combination Product: multi-modal targeted intervention (e.g., cognitive training, exercise, games)

• Registration Number: NCT05014893
• Lead Sponsor: National Research Center for Rehabilitation Technical Aids

Brief Summary

This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.

Detailed Description

Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.

Study Timeline

• Study First Submitted: 2021-08-01
• Study Start: 2021-08-06
• Study First Submitted QC: 2021-08-19
• Study First Posted: 2021-08-20
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-20
• Last Update Posted: 2025-05-22
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Adults being able to walk at least a block, and
• Adults with subjective cognitive decline (SCD), or
• Adults with mild cognitive impairment (MCI), or
• Adults with normal cognitive function

Exclusion Criteria

• Clinical diagnosis of dementia
• Adults who cannot follow the protocal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive training	multi-modal targeted intervention (e.g., cognitive training, exercise, games)	This group receives treatments to improve cognitive function.

Primary Outcome Measures

Name	Time	Method
Change in Cognitive function (MoCA)	Change from Baseline Cognitive test results at 3 months.	The Montreal Cognitive Assessment test is used to assess cognitive function of participants.
Change in Cognitive function (AD8)	Change from Baseline Cognitive test results at 3 months.	The AD8 test is used to assess cognitive function of participants.
Change in Cognitive function (CDR)	Change from Baseline Cognitive test results at 3 months.	The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants.
Change in Cognitive function (SCD-9)	Change from Baseline Cognitive test results at 3 months.	The SCD-9 questionnaire is used to assess cognitive function of participants.

Secondary Outcome Measures

Name	Time	Method
Change in Physical capacity (TUG)	Change from Baseline physical capacity test results at 3 months.	The timed up and go (TUG) test is used to evaluate physical capacity of participants.
Change in Physical capacity (chair standing)	Change from Baseline physical capacity test results at 3 months.	The 30-second chair standing test is used to evaluate physical capacity of participants.

Trial Locations

Locations (1)

National Research Center for Rehabilitation Technical Aids; 🇨🇳 Beijing, Beijing, China