Effect of a Topical Ketamine on Acute and Chronic Pain, Dose Finding
Phase 2
Completed
- Conditions
- Breast Cancer
- Interventions
- Drug: group (B)Drug: group (A)Drug: group (c)
- Registration Number
- NCT03165149
- Lead Sponsor
- Assiut University
- Brief Summary
The aim of this study is to investigate the effect of addition of different doses of Ketamine locally in acute and chronic post-mastectomy pain after breast cancer surgery and on the probability of developing chronic post-mastectomy pain.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
- American society of heart association class I-II female patients
- aged 18-60 years
- scheduled for modified radical mastectomy with axillary dissection for breast carcinoma
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Exclusion Criteria
- known allergy to the study drugs
- significant cardiac-
- respiratory-
- renal or hepatic disease
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group (B) group (B) patients will receive 2 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) a Group (A) group (A) patients will receive 1mg / kg of Ketamine diluted by 20 ml saline (0.9 % ) Group (C) group (c) patients will receive 3 mg / kg of Ketamine diluted by 20 ml saline (0.9 %)
- Primary Outcome Measures
Name Time Method the total amount of morphine consumption 48 hours total amount of rescue analgesia
- Secondary Outcome Measures
Name Time Method pain intensity 48 hours pain intensity measured by Visual analogue scale
Trial Locations
- Locations (1)
South Egypt Cancer Instuite
🇪🇬Assuit, Egypt