Comparison of oral microbiome in orthodontic patients at Sleep Apnea risk with non-risk patients.

Not yet recruiting

• Conditions: Disturbances of salivary secretion,

• Registration Number: CTRI/2020/09/027888
• Lead Sponsor: Priyanka Kapoor

Brief Summary

Establishing the dynamics of oral microbiota in OSA-risk orthodontic patients can help identify the potential population at OSA-risk before further confirmatory diagnosis and also to outline the specific needs in OSA patients regarding oral health care. The current study will attempt to address this gap in current OSA research using flowcytometry and also compare it sequentially with non-orthodontic oral microbial abundance. The advantage of flowcytometry  calculating absolute abundance data for microbial count, a possibility of, compared to relative abundances can allow comparisons between OSA-risk and Non–risk and also critical values can be determined for OSA– risk, if possible.

AIM: To compare difference in oral microbial abundance in OSA risk and non-risk orthodontic patients with flowcytometry within specified oral micro-habitats.

**OBJECTIVES:**

1.    To assess and compare microbial abundance using flowcytometry in OSA risk and non-risk orthodontic patients within 6 oral microhabitats at three different observation times.

2.    To compare microbial abundance using flowcytometry in orthodontic vs non orthodontic patients within 6 oral microhabitats.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-11-09
• Study Start: 2021-11-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 1.Patients in 10-19 years of age.
• 2.Patients requiring fixed orthodontic treatment.

Exclusion Criteria

• 1.Patients requiring removable orthodontic treatment.
• 2.Patients with growth abnormalities/ syndromes/ mentally challenged.
• 3.Patients with reported periodontal problems/ metabolic disturbances.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microbial abundance from 6 different sites in mouth at three different time points using flowcytometry in orthodontic OSA-risk and Non-risk patients	At baseline(Before orthodontic treatment start, 4 weeks, 24 weeks

Secondary Outcome Measures

Name	Time	Method
Prevalence of OSA-risk in Orthodontic patients using questionnaire based screening	At the time of allocation into OSA- Risk and Non-risk groups

Trial Locations

Locations (1)

Faculty of Dentistry, Jamia Millia Islamia; 🇮🇳 South, DELHI, India

Faculty of Dentistry, Jamia Millia Islamia

🇮🇳South, DELHI, India

Priyanka Kapoor

Principal investigator

9891914997

pkapoor@jmi.ac.in