Physical activity in early-onset dementia.
- Conditions
- ENG: - Early-onset dementia- Presenile dementia- Presenile Alzheimer's disease- Frontotemporal dementia- Vascular dementia- Lewy-body dementia- Physical activity- ExerciseNL: - Preseniele dementie- Jong-dementerenden- Preseniele Ziekte van Alzheimer- Frontotemporaal dementie- Vasculaire dementie- Lewy-body dementie- Fysieke activiteit- Bewegen- Sport
- Registration Number
- NL-OMON22143
- Lead Sponsor
- VU University Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
1. Diagnosis of early-onset dementia (onset of complaints < 66 years) (among others: Alzheimer's disease, Vascular dementia, Frontotemporal dementia);
2. Relatively early stage of dementia (MMSE > 15);
Exclusion Criteria
1. Bound to a wheelchair;
2. Neurodegenerative diseases that primarily result in motor impairments, such as Parkinson's disease and Huntington's disease;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Global cognitive functioning: Alzheimer Disease Assessment Scale (ADAS)-COG;<br /><br>2. Mental speed: Trailmaking test A (TMT A);<br /><br>3. Executive functioning (flexibility): Trailmaking test B (TMT B);<br /><br>4. Instrumental Activities of Daily Functioning: Disability Assessment for Dementia (DAD);<br /><br>5. Quality of Life: Dementia-Quality of Life (D-QOL).
- Secondary Outcome Measures
Name Time Method 1. Physical functioning:<br /><br>a. 6 minutes walk test;<br /><br>b. Sit to stand test;<br /><br>c. Physical Activity Scale for the Elderly (PASE).<br /><br>2. Cognitive functioning:<br /><br>a. Mini Mental State Examination (MMSE);<br /><br>b. Face recognition” and Picture recognition” (subtest of the Rivermead Behavioural Memory Test (RBMT));<br /><br>c. Digit Span” (subtest of the Wechsler Memory Scale-Revised (WMS-R);<br /><br>d. Fluency: category fluency and letter fluency;<br /><br>e. Stroop colour word test;<br /><br>f. Symbol substitution” (subtest of the Wechsler Adult Intelligence Scale – III (WAIS-III));<br /><br>g. Number location” (subtest of the Visual Object and Space Perception Battery (VOSP));<br /><br>h. Visual closure” (subtest of the Groninger Intelligence Test (GIT)).<br /><br>3. Questionnaires:<br /><br>a. Dutch translation of the General Self-efficacy Scale;<br /><br>b. Centre for Epidemiologic Studies Depression;<br /><br>c. Rest-activty rhythm: actigraphy.