Stress Hormones, Mood and Women's Sexual Desire (MODEST)

Completed

• Conditions: Hypoactive Sexual Desire Disorder (HSDD)

• Registration Number: NCT01702818
• Lead Sponsor: University of British Columbia

Brief Summary

Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without HSDD. We hypothesize that low levels of DHEA reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where DHEA is produced.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2012-08-27
• Study First Submitted QC: 2012-10-05
• Study First Posted: 2012-10-08
• Primary Completion: 2016-11
• Study Completion: 2016-11
• Status Verified: 2017-05
• Last Update Submitted: 2018-10-15
• Last Update Posted: 2018-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 324

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DHEA levels	Data is collected at 4 time points on 3 separate days	DHEA levels derived from saliva samples.

Secondary Outcome Measures

Name	Time	Method
Depression	data is collected at single time point	Depression will be measured by the Beck Depression Inventory (Beck \& Beamesderfer, 1974)
Perceived stress	data is collected at a single time point	Perceived stress will be measured with the 10-item Perceived Stress Scale (Roberti, Harrington \& Storch 2006)
History of childhood trauma	dat is collected at a single timepoint	History of childhood trauma will be determined with the Childhood Trauma Questionnaire (Bernstein \& Fink, 1995)
Cortisol levels	Data is collected at 4 time points on 3 separate days	Cortisol levels derived from saliva samples.
History of childhood sexual abuse	data is collected at a single time point	History of Childhood Sexual Abuse will be determined with the Childhood Sexual Abuse Measure (Finkelhor, 1979)
PTSD symptoms	data is collected at a single time point	Presence and severity of post traumatic stress disorder symptoms will be determined through the Clinician-Administered PTSD Scale (Blake et al. 1998)
Relationship satisfaction	data is collected at a single time point	Relationship satisfaction will be measured with the Relationship Assessment Scale (Hendrick, 1988) and the Dyadic Adjustment Scale (Spanier, 1976)
Sexual function	data is collected at a single time point	Self-report sexual function will be measured with the Sexual Interest and Desire Inventory (Clayton et al. 2006))

Trial Locations

Locations (1)

British Columbia Centre for Sexual Medicine; 🇨🇦 Vancouver, British Columbia, Canada