Stress Hormones, Mood and Women's Sexual Desire (MODEST)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 324
- 试验地点
- 1
- 主要终点
- DHEA levels
研究概览
简要总结
Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without HSDD. We hypothesize that low levels of DHEA reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where DHEA is produced.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
DHEA levels
时间窗: Data is collected at 4 time points on 3 separate days
DHEA levels derived from saliva samples.
次要结局
- Depression(data is collected at single time point)
- Perceived stress(data is collected at a single time point)
- History of childhood trauma(dat is collected at a single timepoint)
- Cortisol levels(Data is collected at 4 time points on 3 separate days)
- History of childhood sexual abuse(data is collected at a single time point)
- PTSD symptoms(data is collected at a single time point)
- Relationship satisfaction(data is collected at a single time point)
- Sexual function(data is collected at a single time point)
研究者
Lori Brotto
Associate Professor
University of British Columbia