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临床试验/NCT02032355
NCT02032355Unknown不适用

The Feasibility of PetCO2 Prediction Hypotension Under Spinal Anesthesia for Cesarean Section

Geng guiqi1 个研究点 分布在 1 个国家目标入组 6 人开始时间: 2014年1月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
6
试验地点
1
主要终点
value of PetCO2 and changes in artery pressure

研究概览

简要总结

Maternal hypotension is a common side effect after spinal anesthesia for cesarean delivery.Decreased vascular resistance and cardiac output, due to sympathetic blockade1and blood pooling in blocked areas of the body respectively, are main causes of spinal anaesthesia-induced hypotension during Caesarean delivery.

Cardiac output, which has shown to be a better predictor of organ and placental perfusion than arterial blood pressure.Few studies have measured CO after spinal anesthesia in the maternal population.This is largely because of the lack of availability of accurate and reproducible noninvasive measurement techniques. Up to now, preventing hypotension has continued to focus on arterial blood pressure variables, fluid, and ephedrine requirements as markers of cardiovascular status, because these are more easily measured.

Investgators hypothesized that CO and PetCO2, in parturients with the degree of hypotension during spinal anaesthesia, would also have a positive and significant association.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • full-term gestation (>36 and <41 weeks of gestation) with a singleton pregnancy

排除标准

  • emergency cases
  • placenta praevia
  • preeclampsia
  • cardiovascular or cerebrovascular disease
  • morbid obesity with a BMI≥40
  • contraindications to spinal anaesthesia

结局指标

主要结局

value of PetCO2 and changes in artery pressure

时间窗: up to 4 weeks

次要结局

未报告次要终点

研究者

发起方
Geng guiqi
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Geng guiqi

professor

Fudan University

研究点 (1)

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