NCT05091762RecruitingNot Applicable
Effect of Physiological Ischemic Training on Patients With Atherosclerosis
Nanjing First Hospital, Nanjing Medical University1 site in 1 country200 target enrollmentStarted: October 12, 2021Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Endothelium dependent vasodilation
Study Overview
Brief Summary
To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •LDL > 3.11mmol/l and less than 5.63mmol/l;
- •No serious heart, blood vessel and other related diseases;
- •There were no skeletal and muscular diseases affecting sports training;
- •No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);
- •Smoking less than 1 pack / year, no history of drinking.
Exclusion Criteria
- •Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;
- •Pregnant women and people with disabilities;
- •Other circumstances determined by the researcher not suitable for the study.
Outcomes
Primary Outcomes
Endothelium dependent vasodilation
Time Frame: 8 weeks
Percentage of the change
Blood lipid analysis results
Time Frame: 8 weeks
Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein
Secondary Outcomes
- Endothelial repair function(8 weeks)
- The inflammatory state(8 weeks)
Investigators
linaicui
Principal Investigator
Nanjing First Hospital, Nanjing Medical University
Study Sites (1)
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