A study which compares the amount of oxygen and carbon dioxide in arterial blood for patients undergoing removal of gall bladder by micro surgery by general anaesthesia or by spinal anaesthesia

Not Applicable

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2023/11/059836

Lead Sponsor: The Principal, Midnapore Medical College and Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. ASA grade I & II

2. Age group of 18-65 years

3. Elective laparoscopic cholecystectomy

Exclusion Criteria

1. Patients with body mass index (BMI) above 30 kg/m2

2. Acute cholecystitis, pancreatitis or cholangitis

3. Previous open surgery in the upper abdomen

4. Suspected/confirmed common bile duct stones

5. Anxious patient

6. Patients with diagnosed psychological morbidity

7. Presence of contraindications for spinal anaesthesia

8.Inadequate level of sensory block (less than T6) in patients who received spinal anaesthesia

9. Severe systemic disease (ASA III & IV)

10. Known allergy to any drug to be used in the study

11. Conversion to general anaesthesia from spinal anaesthesia due to operative difficulty, anxiety of the patient or pain (shoulder or abdominal) not controlled by analgesic dose of ketamine (0.5 mg/kg).

12. Any contraindication to Arterial Cannulation

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare partial pressure of carbon dioxide (PaCO2), oxygen (PaO2) <br/ ><br>and pH of arterial blood of the patients undergoing laparoscopic cholecystectomy under <br/ ><br>general anaesthesia with the patients undergoing laparoscopic cholecystectomy under spinal <br/ ><br>anaesthesia at the beginning of the operation and then at 15 min interval up to one hour or end of the procedure (which ever is earlier)Timepoint: To compare partial pressure of carbon dioxide (PaCO2), oxygen (PaO2) <br/ ><br>and pH of arterial blood of the patients at baseline, 15 mins, 30 mins, 45 mins, 60 mins

Secondary Outcome Measures

Name	Time	Method
Consumption of post operative analgesic in 1st 24 hoursTimepoint: 24 hours after completion of surgery;Mean arterial pressure and heart rateTimepoint: baseline and then every 5 mins for 1 hour;Patient satisfaction score and surgeon satisfaction scoreTimepoint: 24 hours after surgery completion;To compare oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2) at 5 min <br/ ><br>interval upto one hour or end of the procedure (whichever is earlier).Timepoint: baseline, 5, 10,15, 20, 25,30, 35, 40, 45, 50, 55, 60 min;To compare the post operative complication like hypotension, hypertension, tachycardia, <br/ ><br>bradycardia, sore throat, urinary retention, nausea vomiting (PONV) between the two groups.Timepoint: After completion of surgery and after 24 hours