Evaluation of the Possible Effect of Inspiratory Muscle Training on Inflammation Markers and Oxidative Stress in Childhood Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 2
- 主要终点
- Inflammatory marker
研究概览
简要总结
As inflammation and oxidative stress increase in asthma patients, the severity of symptoms and clinical findings increase. Therefore, this study was planned to evaluate the possible effect of inspiratory muscle training (IMT) on inflammation markers and oxidative stress in childhood asthma.
The study included asthma patient; 35 routine medication, 35 drug therapy and inspiratory muscle training (IMT), and 35 healthy total 105 children aged 8-17 years. Demographic information and hemogram values were recorded. Functional capacity was evaluated with the 6-minute walking test, quality of life PedsQL, respiratory muscle strength oral pressure measuring device, respiratory function test, dyspnea severity with Modified Borg Scale. C-Reactive Protein (CRP), Periostin, Transforming Growth Factor-βeta (TGF-β), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) were analyzed. IMT was given with a Threshold IMT device for 7 days/6 weeks at 30% of maximal inspiratory pressure, and then a second evaluation was made.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 8 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have been diagnosed with asthma,
- •Between the ages of 8-17,
- •No asthma attack,
- •Cooperating with the study,
- •Without cerebral palsy, mental retardation or any other major neurological diagnosis,
- •Agreeing to participate in the study,
- •Cases whose medication has not been changed for at least three weeks.
排除标准
- •Presence of kyphoscoliosis that may affect respiration,
- •Having advanced postural alignment problem,
- •Having mental problems,
- •Having neuromuscular disease,
- •Making changes in the medications used in the last three weeks,
- •Presence of inflammatory diseases such as juvenile idiopathic arthritis.
研究组 & 干预措施
Inspiratory muscle training group
Threshold IMT was given this group. Applied for 7 days 6 weeks.
干预措施: Inspiratory muscle training (Other)
Inspiratory muscle training group
Threshold IMT was given this group. Applied for 7 days 6 weeks.
干预措施: Used routine medicine (Other)
Used routine medicine group
Followed 6 weeks
干预措施: Used routine medicine (Other)
Control Group
Health children
干预措施: Control group (Other)
结局指标
主要结局
Inflammatory marker
时间窗: 6 weeks
We assessed C reaktive protein from Blood sample
Oxidative stress
时间窗: 6 weeks
We assessed Total oxidative level.
次要结局
- functional capacity(6 weeks)
- Quality life(6 weeks)
- Pulmonary function test(6 weeks)
- Respiratory muscle strength(6 weeks)
研究者
Ozden Gokcek
Principal Investigator
Ege University