Efficacy of Serratus Posterior Superior Intercostal Plane Block (SPSIPB) on Perioperative Analgesia and Inflamatory Markers in Breast Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 主要终点
- is to calculate total perioperative analgesia consumption throughout (24hours).
研究概览
简要总结
To study the efficiacy of serratus posterior superior block in controlling perioperative breast cancer surgery pain and its effect on inflamatory markers.
详细描述
Back ground The presence of pain during the initial course of treatment in women with early-stage breast cancer was associated with significantly higher levels of c-reactive protein(CRP) ,interleukin-7(IL-7)and interleukin-13(IL-13) There is evidence of effectiveness of regional block in controlling inflamatory markers Serratus posterior superior intercostal plane block (SPSIPB) is a novel Regional technique that provides analgesia in the hemithorax, shoulder, and back of the neck which proved its efficacy in controlling pain after Video assisted thoracoscopic surgery there are little epidemiological data on (SPSIPB)usage in masectomy and lumpectomy procedures and its effect on inflamatory markers
Methodology:
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Type of the Study: Randomized prospective comparative controlled double-blinded study
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Study Setting: Ain Shams University Hospitals
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Study Period: One year after approval of the protocol.
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Place :Ain shams university hospitals
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Study Population: Adult patients who will undergo breast cancer surgey.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Adults undergoing unilateral breast surgery under general anesthesia
- •Age 21 to 60 years with body mass index (BMI)=18 to 25 kg/m2
- •American Society of Anesthesiologists (ASA) grade I-III.
排除标准
- •Patients with Long-time use of analgesic drugs
- •Past history of chest surgery,
- •Allergy to local anesthetics,
- •Systemic infection,
- •Cognitive and language disorders precluding participation,
- •Patients with coagulopathy,anticoagulant users
- •hemodynamic unstable patients
- •Patients with neurology, spinal, psychiatry diseases
- •infection at block site
- •patients refused to participate in the study .
研究组 & 干预措施
will receive serratus posterior superior block using bupivacaine
between the SPSM and the 3rd rib after using a test dose of 1- 2 mL saline and Following hydro-dissection,30ml 0.25%bupivacaine will be injected.
干预措施: Analgesia mangement group A,B (Drug)
Arm B: (control group) patients will only receive general anesthesia without block.
Narcotic postoperative
干预措施: Analgesia mangement group A,B (Drug)
结局指标
主要结局
is to calculate total perioperative analgesia consumption throughout (24hours).
时间窗: 24 hour postoperative
次要结局
未报告次要终点