BOchum heaRt failurE in Aortic Stenosis study - Prospective diagnostic study to investigate the hemodynamic and cell biological basis of an irreversible left ventricular failure in severe aortic stenosis

• Conditions: I35.0; I42.8; Aortic (valve) stenosis; Other cardiomyopathies

• Registration Number: DRKS00005623
• Lead Sponsor: Medizinische Klinik II, Kardiologie und AngiologieBG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Inclusion criteria study group aortic stenosis and left ventricular failure
- Severe aortic stenosis ( valve area < 1 cm ²)
- Left ventricular dysfunction (left ventricular ejection fraction = 40%)
- Symptoms of heart failure (NYHA II -IV)
- Age = 18 years
- Life expectancy > 1 years
- Consent to participate in the study

Inclusion criteria control group aortic stenosis without left ventricular failure
- Severe aortic stenosis ( valve area < 1 cm ²)
- Received left ventricular ejection fraction ( = 50%)
- Symptoms of heart failure (NYHA II -IV)
- Age = 18 years
- Life expectancy > 1 years
- Consent to participate in the study

Exclusion Criteria

- Active endocarditis
- Previous myocardial infarction
- Previous heart surgery
- Concurrent serious stenosis or insufficiency of the mitral valve
- Concurrent serious insufficiency of the aortic valve
- Pregnancy, lactation

Study & Design

• Study Type: observational
• Study Design: Not specified