WItten heaRt failurE in Aortic Stenosis study - Prospective diagnostic study to investigate the hemodynamic basis of an irreversible left ventricular failure in severe aortic stenosis

Recruiting

Conditions: I35.0
I42.8
Aortic (valve) stenosis
Other cardiomyopathies

Registration Number: DRKS00009993

Lead Sponsor: Kardiogische Klinik, Marien-Hospital Witten, Ruhr-Universität Bochum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Inclusion criteria study group aortic stenosis and left ventricular failure
- Severe aortic stenosis ( valve area < 1 cm ²)
- Left ventricular dysfunction (left ventricular ejection fraction = 40%)
- Symptoms of heart failure (NYHA II -IV)
- Age = 18 years
- Life expectancy > 1 years
- Consent to participate in the study

Inclusion criteria control group aortic stenosis without left ventricular failure
- Severe aortic stenosis ( valve area < 1 cm ²)
- Received left ventricular ejection fraction ( = 50%)
- Symptoms of heart failure (NYHA II -IV)
- Age = 18 years
- Life expectancy > 1 years
- Consent to participate in the study

Exclusion Criteria

- Active endocarditis
- Previous heart surgery
- Concurrent serious stenosis or insufficiency of the mitral valve
- Concurrent serious insufficiency of the aortic valve
- Pregnancy, lactation

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of reversible and irreversible left ventricular failure in terms of the end-systolic pressure-volume relationship (ESPVR) - measured with conductance catheter - before aortic valve replacement

Secondary Outcome Measures

Name	Time	Method
Comparison of reversible and irreversible left ventricular failure:<br>- All-cause mortality (one-year)<br>- Cardiovascular mortality (one-year)<br>- Hospitalization for heart failure (within the first year after aortic valve replacement)<br>- Distance in the 6-minute walk test before and 3 months after aortic valve replacement<br>