Aortic Stenosis * Identification of high-risk valve pathology using STRESS physiology (AoS-STRESS)
- Conditions
- aortic valve stenosisnarrowed heart valve10046973
- Registration Number
- NL-OMON43812
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
-Age * 18 years.
-Undergoing TAVI or balloon valvuloplasty for standard clinical indications/undergoing coronary catheterization and have had an echo with a moderate aortic stenosis in the last 3 months
-Ability to understand and the willingness to sign a written informed consent.
-Unrevascularized and severe coronary artery disease (for example a 90% diameter stenosis or FFR<0.7 in the proximal left anterior descending artery) that in the opinion of the primary TAVI/BAV operator would produce significant ischemia during dobutamine infusion.
-Significant aortic regurgitation, mitral valve disease, tricuspid regurgitation, or intracardiac shunt that would invalidate thermodilution cardiac output or the interpretation of transvalvular flow across the aortic valve.
-Co-existing hypertrophic cardiomyopathy.
-Atrial fibrillation or tachycardia with rapid ventricular response, a history of significant ventricular tachycardia or fibrillation, or an implanted cardiac defibrillator whose treatment thresholds would be reached during dobutamine infusion.
-Known hypersensitive response to dobutamine.
-Recent (within 3 weeks prior to cardiac catheterization) ST-segment elevation myocardial infarction (STEMI) in any arterial distribution.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Transvalvular pressure gradient as a function of transvalvular flow</p><br>
- Secondary Outcome Measures
Name Time Method <p>Classic echocardiographic parameters and subsequent clinical events</p><br>