Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

Recruiting

• Conditions: Cardiovascular System; Health

• Registration Number: NCT06663267
• Lead Sponsor: The Affiliated Hospital of Hangzhou Normal University

Brief Summary

The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:

1. How do meteorological factors and air pollution affect cardiovascular system?

2. What is the interaction between meteorological factors and air pollution on cardiovascular system?

Participants will:

1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound.

2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

Detailed Description

The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.

Study Timeline

• Study First Submitted: 2024-05-12
• Status Verified: 2024-10
• Study First Submitted QC: 2024-10-26
• Last Update Submitted: 2024-10-26
• Study First Posted: 2024-10-29
• Last Update Posted: 2024-10-29
• Study Start: 2024-11
• Primary Completion: 2027-05
• Study Completion: 2028-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 350000

Inclusion Criteria

·Relevant records in the physical examination database shall be ≥3 times

·≥18 years old

Exclusion Criteria

• Relevant records in the physical examination database shall be ≥３times
• Serious heart and lung diseases
• Malignant tumors
• Serious mental illness in the past

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Troponin	The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L.
Blood pressure	The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg.

Secondary Outcome Measures

Name	Time	Method
Left ventricular ejection fraction（LVEF）	The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Left ventricular ejection fraction（LVEF）data were obtained by Cardiac color ultrasound data recorded in the diagnosis and treatment system, with unit of %
White cell count	The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	White cell count data were obtained by blood routine blood data recorded in the diagnosis and treatment system, with unit of 10\^9/L
Controlled Attenuation Parameter（CAP）	The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Controlled Attenuation Parameter（CAP）data were obtained by Diagnosis of hepatic fibrosis data recorded in the diagnosis and treatment system, with unit of dB/m.
ST segment of electrocardiogram	The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	ST segment were obtained by Electrocardiogram (ECG) recorded in the diagnosis and treatment system with unit of mV.
Degree of coronary artery stenosis	The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Degree of coronary artery stenosis data were obtained by Coronary CTA data recorded in the diagnosis and treatment system, with unit of µg/L
Weight	The weight data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Weight data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of kg
Height	The height data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Height data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of cm
Urinary glucose	The urinary glucose data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.	Urinary glucose data were obtained by Urine routine data recorded in the diagnosis and treatment system, with unit of mmol/L.

Trial Locations

Locations (1)

MingWei Wang; 🇨🇳 Hanzhou, Zhejiang, China