Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.

Recruiting

• Conditions: Eczema; Bronchitis; Asthma; Urticaria; Allergic Rhinitis; Chronic Obstructive Pulmonary Disease(COPD); Emphysema; Bronchiectasis Adult; Atopic Dermatitis
• Interventions: Other: Climate and environment in Sanya

• Registration Number: NCT05330637
• Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Brief Summary

To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.

Detailed Description

The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.

1. The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.

2. The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.

3. The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.

Study Timeline

• Study Start: 2022-03-03
• Study First Submitted: 2022-03-18
• Study First Submitted QC: 2022-04-08
• Study First Posted: 2022-04-15
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-07
• Last Update Posted: 2023-09-11
• Primary Completion: 2023-12-31
• Study Completion: 2025-04-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
• 3-12 years-old children in Sanya;
• Agree to participate this study.

Exclusion Criteria

• Disagree to participate this study;
• Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
• Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya	Climate and environment in Sanya	Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Children with asthma in Sanya	Climate and environment in Sanya	Children with asthma have being exposure to tropical climate and environment in Sanya for years.
Migratory old people with eczema from northern China in Sanya	Climate and environment in Sanya	Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Migratory old people with allergic rhinitis from northern China in Sanya	Climate and environment in Sanya	Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Children with allergic rhinitis in Sanya	Climate and environment in Sanya	Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years.
Migratory old people with asthma from northern China in Sanya	Climate and environment in Sanya	Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Migratory old people with atopic dermatitis from northern China in Sanya	Climate and environment in Sanya	Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Children with urticaria in Sanya	Climate and environment in Sanya	Children with urticaria have being exposure to tropical climate and environment in Sanya for years.
Migratory old people with urticaria from northern China in Sanya	Climate and environment in Sanya	Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.
Children with atopic dermatitis in Sanya	Climate and environment in Sanya	Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years.
Children with eczema in Sanya	Climate and environment in Sanya	Children with eczema have being exposure to tropical climate and environment in Sanya for years.

Primary Outcome Measures

Name	Time	Method
The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.	3 year	The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire..

Secondary Outcome Measures

Name	Time	Method
Asthma life quality of migratory old people with asthma.	1-3 year	Quality of life is assessed through questionnaires of "Asthma Quality of Life Questionnaire (AQLQ)".
Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.	1-3 year	Veinal blood was extracted to detect allergens.
Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.	1-3 year	Inflammatory factors such as esophageal granulocytes and eosinophils will be detected to assess inflammatory status of the migratory old people.
The change of asthma incidence rate in migratory old people .	1-3 year	Diagnosis and severity grading of asthma is based on the "American Thoracic Society" or the "National Heart, Lung, and Blood Institute guidelines."
Asthma control of migratory old people with asthma.	1-3 year	Quality of life is assessed through questionnaires of "Asthma Control Questionnaire (ACQ) ".
Lung function of migratory old people with asthma or COPD.	1-3 year	Lung function is assessed through simple lung function test using spirometry.
The respiratory function of migratory old people with COPD.	1-3 year	Lung function is assessed through Saint George Respiratory Questionnaire (SGRQ).

Trial Locations

Locations (1)

Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University; 🇨🇳 Sanya, Hainan, China