Renal Effects of Levosimendan in Cardiac Surgery Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Change of plasma creatinine (Difference in renal function)
研究概览
简要总结
Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing cardiac surgery (OPS 5-35 bis 5-37) between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital
排除标准
- •Patients younger 18
- •Preexisting renal insufficiency
结局指标
主要结局
Change of plasma creatinine (Difference in renal function)
时间窗: last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4
Only in patients not requiring renal replacement therapy
Change of urine output after surgery (difference in renal function)
时间窗: post-op day 1, 2, 3, 4
Only in patients not requiring renal replacement therapy
Cumulative incidence and duration of hemodialysis (Difference in renal function)
时间窗: last day of hospital stay
次要结局
- Cumulative Length of stay (hospital and ICU)(last day of hospital stay)
- In-hospital mortality(last day of hospital stay)
研究者
Jan Braun, MD
PD Dr. med.
Charite University, Berlin, Germany