A clinical trial to study the effect of two drugs Lignocaine and Dexmedetomidine on surgical bleed in trans-nasal endoscopic surgeries.
Phase 2
Completed
- Conditions
- Health Condition 1: null- Surgical field quality in patients undergoing elective trans-nasal endoscopic surgeries.
- Registration Number
- CTRI/2017/11/010557
- Lead Sponsor
- PGIMER Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 101
Inclusion Criteria
1.ASA I And II
2.Patients undergoing elective trans-nasal endoscopic surgeries
Exclusion Criteria
Patients with:
1.Known cerebro-vascular disease
2.Known coagulation defects
3.Known hypersensativity to the drug.
4.History of hepatic or renal insufficiency
5.Body mass index >35
6.Poorly controlled hypertension
7.Use of beta-blockers
8.History of bradycardia episodes/atrio-venticular block and conduction defects.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess if intravenous Lignocaine infusion provides better surgical field as compared to Dexmedetomidine in patients undergoing elective trans-nasal endoscopic surgeries.Timepoint: At 30 mins interval from intubation
- Secondary Outcome Measures
Name Time Method Estimated total blood loss.Timepoint: At the end of the surgery.;Requirement of other agents for controlled hypotension with their doses.Timepoint: 1.At baseline <br/ ><br>2.After intubation <br/ ><br>3.2 mins after local adrenaline instillation. <br/ ><br>4.At 15 mins interval from the intubation time. <br/ ><br>;Variations in hemodynamic parameters such as heart rate and blood pressure.Timepoint: 1.At baseline <br/ ><br>2.After intubation <br/ ><br>3.2 mins after local adrenaline instillation. <br/ ><br>4.At 15 mins interval from the intubation time. <br/ ><br> <br/ ><br>