Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas

Completed

• Conditions: Carcinoma, Hepatocellular
• Interventions: Procedure: transcatheter arterial chemoembolization

• Registration Number: NCT05352204
• Lead Sponsor: Zhejiang University

Brief Summary

Micronecrosis is a novel pathological feature of hepatocellular carcinoma (HCC). This study was aimed at evaluating the effect of tumor micronecrosis on postoperative transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinomas, and further exploring the value of micronecrosis for guiding TACE in HCC management.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-30
• Primary Completion: 2022-01-01
• Study Completion: 2022-04-14
• Study First Submitted: 2022-04-22
• Study First Submitted QC: 2022-04-22
• Study First Posted: 2022-04-28
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-11
• Last Update Posted: 2023-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

• (1) pathologically confirmed HCC (2) achievement of R0 resection.

Exclusion Criteria

• (1) simultaneous presence of other tumors ; (2) receipt of preoperative anti-tumoral treatments; (3) concurrent treatment with other antitumoral therapies in combination with TACE; (4) tumor necrosis that could be observed by gross examination; (5) a lack of necessary preoperative laboratory test results.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
micronecrosis(+) group	transcatheter arterial chemoembolization	-

Primary Outcome Measures

Name	Time	Method
overall survival	after liver resection until June 1, 2020	the number of months from the date of surgery to the date of the last follow-up visit or time of death.

Secondary Outcome Measures

Name	Time	Method
disease-free survival	after liver resection until June 1, 2020	the number of months from the date of surgery to the date of first confirmable recurrence or death

Trial Locations

Locations (2)

the First Affiliated Hospital, Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China

the First Affiliated Hospital, School of Medicine, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China