CTRI/2025/06/089163尚未招募不适用
Elucidating the role of altered mitochondrial function and inflammatory signaling in insulin resistance to Type 2 Diabetes Mellitus
Intramural Fund from Manipal Academy of Higher Education (MAHE)1 个研究点 分布在 1 个国家目标入组 69 人开始时间: 2025年6月27日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 69
- 试验地点
- 1
- 主要终点
- Altered biochemical parameters can be expected in T2DM patients.
研究概览
简要总结
Our studies will help us understand the relationship between mitochondrial dysfunction and innate immune responses to insulin resistance in T2DM patients which could lay foundation for further temporal studies focusing on the compensated innate immune responses in T2DM thereby, opening new approaches in the management of hyperglycemia, improved insulin sensitivity and delay the on-set of secondary complications of T2DM.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Male
入选标准
- •1.Men between 40 to 45yrs of age.
- •No history of diabetes mellitus (HbA1C less than or equal to 5.7%) 3.No major co-morbidity
- •Individuals with no history of tobacco/nicotine usage for past 3 months from the point of recruitment for the study.
- •Individuals with no history of consumption of alternative medicines for 3 months from the point of recruitment (Ayurverda, Homeopathy, Siddha, Naturopathy, Unani etc.)
- •Individuals screened and cleared for the following parameters: fasting and post prandial glucose, fasting insulin, CRP, Lipid profile, Plasma lactate, HbA1C.
- •Individuals with no evidence of any active infection or chronic disease.
排除标准
- •1.Individuals under 40yrs and above 45yrs of age.
- •2.Individuals with the history of comorbidity.
- •3.Individuals with history of smoking / nicotine usage / consumption of alternative medicine/ dietary changes as per alternative medicine.
- •4.Women recruits are excluded from the study.
- •5.Individuals who have undergone any surgical procedures within the past three months prior to recruitment will be excluded from participation in the study.
- •6.Individuals who are obese-BMI more than 30.
结局指标
主要结局
Altered biochemical parameters can be expected in T2DM patients.
时间窗: Baseline i.e. 0th time point
次要结局
- Understanding the relationship between mitochondrial dysfunction & innate immune responses to IR in T2DM patients.(Baseline i.e. 0th time point)
研究者
Dr Ranita Ghosh Dastidar
Kasturba Medical College, Manipal, MAHE
研究点 (1)
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