Microbiome and lower respiratory tract infections in childre

Completed

Conditions: bronchitis or pneumonia
Lower respiratory tract infections
10019815

Registration Number: NL-OMON44725

Lead Sponsor: Spaarne Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 975

Inclusion Criteria

All groups:
Children * 4 weeks and * 5 years and;Non-severe LRTI group:
Hospitalized for a LRTI at a general pediatric ward. ;Severe LRTI group:
Hospitalized at the intensive care ward for a severe LRTI;Control group must fulfil all the following criteria:
1. Children matched with LRTI case for age (in years). In addition children < 1 year will be matched for months in two categories: 4 weeks - 6 months or 6 months - 1 year.
2. Matched with hospital admission date of LRTI case + maximal two weeks.
3. Matched for gender.
4. No fever and/or respiratory tract infection (except rhinitis) in the previous four weeks.
5. No antibiotics in the previous 3 months.

Exclusion Criteria

- Severe concomitant disease (severe congenital heart disease, bronchopulmonary dysplasia, prematurity <32 weeks, cystic fibrosis, sickle cell disease, congenital or acquired immunodeficiency disorders, cardiovascular disease, neuromuscular disorders, oncology patients or major congenital anomalies) and/or
- Nosocomial infection and/or
- Language barrier

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>NP microbiome composition and viral presence in the nasopharynx of children<br /><br>hospitalized for a LRTI and in healthy age-and gender-matched controls. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1.NP microbiome composition and viruses of LRTI cases after recovery.<br /><br>2.Clinical data from the medical record, routine chest X-ray results and<br /><br>routine laboratory blood parameters of children hospitalized for LRTI.<br /><br>3.Microbiota in saliva (oral cavity) and faeces (intestines). </p><br>