Susceptibility to respiratory tract infections

Recruiting

• Conditions: ATEMWEGSINFEKTANFLLIGKEIT; J00; J01; J02; J03; J04; J05; J06; J12; J13

• Registration Number: DRKS00003381
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-12-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

Screening study (step 1)
20-70 years of age
- comprehension of German language
- resident of Freiburg and Breisgau/Hochschwarzwald
- consent for participation in questionnaire study.

Supplementary study (step 2):
same as above
- lack of indicated co-morbidities
- consent for participation in supplementary study including consent to 1) provide a saliva samples as source of genomic DNA, 2) to allow study nurse to contact participant and primary care physician to validate phenotype
- highest 7.5% of RTI score (group 1)
- lowest 40% RTI score (group 2).

Exclusion Criteria

Screening study:
- Residence outside study region
- non-comprehension of German language
- lack of consent

Supplementary study:
same as above
- prevalence of indicated co-morbidities
- lack of consent for supplementary study
- RTI score outside range of interest

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the proportion and characteristics of individuals in Germany with frequent and/or severe RTI of unknown cause.

Secondary Outcome Measures

Name	Time	Method
To identify genetic susceptibility biomarkers for this phenotype for subsequent prospective validation in independent study populations.