iver involvement during acute respiratory tract infection in children and adolescents

Recruiting

Conditions: acute respiratory tract infectionshepatic infection
J00-J06
B90-B94
K70-K77
Acute upper respiratory infections
Sequelae of infectious and parasitic diseases
Diseases of liver

Registration Number: DRKS00005592

Lead Sponsor: Klink für Kinder und JugendmedizinEVK Hamm

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 1000

Inclusion Criteria

1. Patients between 1 and 18 years old.
2. Diagnosis of uncomplicated upper or lower respiratory tract infection (rhinitis, sinusitis, pharyngitis, bronchitis, interstitial or central pneumonia). Diagnosis of pneumonia not exceeding 30% of included patients.
3. Written informed consent of patients and their parents.
4. For hospitalized patients blood sampling and nasal lavage should take place within 24 hours after hospital admission.

Exclusion Criteria

1. Severe infections requiring assisted respiration or circulatory support via drug therapy.
2. Known or suspected congenital malformation or metabolic dysfunction which may influence study results.
3. Bronchopneumonia, pleuropneumonia and segmental pneumonia.
4. Infections already existing for more than five days.
5. Pre-existing icterus.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detection of the frequency of liver involvement during acute respiratory tract infections in pediatric patients.<br>Blood sampling at study entry and 3-7 days later for quantification of serum levels of liver enzymes.

Secondary Outcome Measures

Name	Time	Method
Which viruses are mainly responsible for the respiratory infections?<br>Which viruses may cause hepatic infection?<br>Identification of viral pathogens by means of PCR (Polymerase-Chain-Reaction).