A long-term observational study evaluating the presentation and management of acute respiratory tract infections in primary care across Europe

Not Applicable

• Conditions: Observation of early presentation and management of acute respiratory illness in the community; Respiratory

• Registration Number: ISRCTN10204126
• Lead Sponsor: European Clinical Research Alliance for Infectious Diseases (Ecraid)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-20
• Last Update Posted: 22 April 2024
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 8400

Inclusion Criteria

Eligible patients will be of any age consulting (telephone, video, face to face) with a participating primary health care facility with:
1. Symptoms suggestive of an acute lower respiratory infection with cough as the predominant symptom, with illness duration less than 28 days,
AND/OR
2. Symptoms suggestive of an acute upper respiratory infection with a sore throat and/or coryza as the predominant symptom, with illness duration of less than 14 days
AND/OR
3. Other symptoms suggestive of COVID-19, Influenza, RSV
4. Participant or legal guardian(s) willing and able to provide informed consent and comply with study procedures

(added 28/02/2024)
POS-ARI-PC-001 Study
1. Eligible patients will be 60 years of age and over consulting (telephone, video, or face-to-face in the practice, or home visit ) with a participating primary health care facility with:
1.1. Symptoms suggestive of an acute lower RTI with new or increased cough as the predominant symptom, with illness duration <=7 days; AND/OR
1.2. Symptoms suggestive of an acute upper RTI with sore throat and/or coryza as the predominant symptoms, with illness duration <=7 days; AND
1.3. Willing and able to provide informed consent and have a swab taken

Exclusion Criteria

Patients will not be eligible if:
1. According to the judgement of the recruiting clinician, they will not be able to comply with study procedures, for example, because they do not understand the language in which the study is being conducted locally (and have no one to help and translate for them); have a serious psychiatric disorder; or are terminally ill
2. Symptoms of presumed non-infective origin
3. Participant requires admission to the hospital on the day of inclusion. Additional in/exclusion criteria might apply to embedded studies and will be described in the SSA or ISA

(added 28/02/2024)
POS-ARI-PC-001 Study
As per the POS-ARI-PC CORE Protocol, with one exception: patients needing hospitalisation can be recruited into the study if timing allows. Patients can provide a swab and decide not to participate in the follow-up procedures.

Study & Design

• Study Type: Observational
• Study Design: Not specified