Predictability of the Pulse Pressure Variation During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia
试验速览
- 阶段
- 不适用
- 入组人数
- 172
- 试验地点
- 1
- 主要终点
- Changes of heart rate and systolic arterial blood pressure from baseline values immediately before tracheal intubation
研究概览
简要总结
The purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing general anesthesia induction with intravenous anesthesia using propofol and remifentanil
- •Patients requiring invasive arterial blood pressure monitoring for the surgery
排除标准
- •Refusal of consent
- •Patients with heart disease (symptomatic valvular heart disease, intracardiac shunt, pulmonary hypertension with pulmonary systolic arterial pressure exceeding 40mmHg)
- •FEV1 ≤ 50% predicted FEV1
- •Patients with chronic renal failure
- •ASA class IV, V, VI
- •Systolic arterial blood pressure below 90mmHg before induction of anesthesia
研究组 & 干预措施
P(+)V(+)
PPV>14% before anesthesia induction, HES 6ml/kg infused
干预措施: PPV>14% (Other)
P(+)V(+)
PPV>14% before anesthesia induction, HES 6ml/kg infused
干预措施: Volume loading (Drug)
P(+)V(-)
PPV>14% before anesthesia induction, no additional volume infused
干预措施: PPV>14% (Other)
P(-)V(+)
PPV<14% before anesthesia induction, HES 6ml/kg infused
干预措施: Volume loading (Drug)
P(-)V(+)
PPV<14% before anesthesia induction, HES 6ml/kg infused
干预措施: PPV<14% (Other)
P(-)V(-)
PPV<14% before anesthesia induction, no additional volume infused
干预措施: PPV<14% (Other)
结局指标
主要结局
Changes of heart rate and systolic arterial blood pressure from baseline values immediately before tracheal intubation
时间窗: Three minutes after anesthesia agent injection
First, we measure the baseline heart rate and systolic arterial blood pressure and calculate the baseline heart rate and blood pressure. At 3 minutes after anesthesia agent injection we record the heart rate and blood pressure, and perform endotracheal intubation. Then we calculate the percentile change of blood pressure and heart rate from the baseline values.
次要结局
- Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes after intubation(Three minutes after endotracheal intubation)
- Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes before intubation(Three minutes before endotracheal intubation)
研究者
Jae-Hyon Bahk, MD, PhD
Professor
Seoul National University Hospital