Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction

Not Applicable

Completed

• Conditions: Fluid Responsiveness Predictability
• Interventions: Drug: Fluid loading (Voluven)

• Registration Number: NCT01819571
• Lead Sponsor: Yonsei University

Brief Summary

The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2013-03-14
• Study First Submitted QC: 2013-03-26
• Study First Posted: 2013-03-27
• Primary Completion: 2013-10
• Study Completion: 2013-10
• Status Verified: 2014-02
• Last Update Submitted: 2014-02-17
• Last Update Posted: 2014-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• Patients older than 20 years
• scheduled for elective coronary artery bypass grafting
• normal diastolic function (E/E' < 8) or diastolic dysfunction (E/E' >15) according to preoperative Echocardiographic evaluation

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Exclusion Criteria

• arrythmia,
• reduced left ventricular function (ejection fraction < 40%)
• valvular heart disease requiring concomitant surgical correction
• pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg)
• peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection)
• end-stage renal disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Diastolic dysfunction group	Fluid loading (Voluven)	-
Normal diastolic function group	Fluid loading (Voluven)	-

Primary Outcome Measures

Name	Time	Method
predictability of pulse pressure variation (PPV) on fluid responsiveness in patients with coronary disease who have normal diastolic function and diastolic dysfunction.	10 minutes after fluid replacement	After induction of anesthesia and applying mechanical ventilation, hemodynamic parameters (including PPV measured by Philips IntelliVue MP 70®) were recorded

Trial Locations

Locations (1)

Department of anesthesiology and pain medicine; 🇰🇷 Seoul, Korea, Republic of