Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition

Completed

• Conditions: Sternotomy; Thoracic Surgical Procedures; Cardiac Surgical Procedures
• Interventions: Procedure: Valsalva maneuver; Other: Fluid loading

• Registration Number: NCT02457572
• Lead Sponsor: Samsung Medical Center

Brief Summary

Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal. The investigators evaluated whether PPV measured during Valsalva maneuver can predict fluid responsiveness after sternotomy.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2015-04-22
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Study First Submitted QC: 2015-05-26
• Study First Posted: 2015-05-29
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-11
• Last Update Posted: 2015-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Adult patients undergoing elective off-pump coronary arterial bypass grafting

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Exclusion Criteria

• Preoperative LV EF <= 35%
• Moderate or severe valvular heart disease
• Cardiac arrhythmia
• Intracardiac shunt
• Severe renal or liver disease
• Moderate to severe pulmonary hypertension (mean PAP > 35 mmHg)
• Patients with bullous lung disease or combined pneumothorax

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Valsalva maneuver	Fluid loading	This is an observational study and as a diagnostic intervention, subjects in the study would receive valsalva maneuver. Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration. The investigators perform this procedure to every patients and do not assign this intervention to the subjects of the study.
Valsalva maneuver	Valsalva maneuver	This is an observational study and as a diagnostic intervention, subjects in the study would receive valsalva maneuver. Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration. The investigators perform this procedure to every patients and do not assign this intervention to the subjects of the study.

Primary Outcome Measures

Name	Time	Method
Pulse pressure variation during Valsalva maneuver	during Valsalva maneuver

Secondary Outcome Measures

Name	Time	Method
Pulse pressure variation after sternotomy	5 min after sternotomy

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of