Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition

Completed

• Conditions: Sternotomy; Thoracic Surgical Procedures; Cardiac Surgical Procedures

• Registration Number: NCT02457572
• Lead Sponsor: Samsung Medical Center

Brief Summary

Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal. The investigators evaluated whether PPV measured during Valsalva maneuver can predict fluid responsiveness after sternotomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2015-04-22
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Study First Submitted QC: 2015-05-26
• Study First Posted: 2015-05-29
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-11
• Last Update Posted: 2015-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Adult patients undergoing elective off-pump coronary arterial bypass grafting

Exclusion Criteria

• Preoperative LV EF <= 35%
• Moderate or severe valvular heart disease
• Cardiac arrhythmia
• Intracardiac shunt
• Severe renal or liver disease
• Moderate to severe pulmonary hypertension (mean PAP > 35 mmHg)
• Patients with bullous lung disease or combined pneumothorax

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulse pressure variation during Valsalva maneuver	during Valsalva maneuver

Secondary Outcome Measures

Name	Time	Method
Pulse pressure variation after sternotomy	5 min after sternotomy

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of