Interactions of Brain Regions in Visuomotor Adaptation

Not Applicable

• Conditions: Deep Brain Stimulation; High Intensity Focused Ultrasound
• Interventions: Behavioral: Behavioral Assessment

• Registration Number: NCT04190940
• Lead Sponsor: University of Virginia

Brief Summary

The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance "on" and "off" thalamic electrical stimulation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-18
• Study First Submitted: 2019-11-17
• Status Verified: 2019-12
• Study First Submitted QC: 2019-12-05
• Last Update Submitted: 2019-12-05
• Study First Posted: 2019-12-09
• Last Update Posted: 2019-12-09
• Primary Completion: 2021-04-17
• Study Completion: 2021-04-17

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor
• Able to provide informed consent and complete study procedures
• Must speak English
• Age 18-85

Exclusion Criteria

• Not receiving one of the specified inclusion criteria
• Unable to provide consent or complete study procedures
• Women who self-report pregnancy
• Patients who are currently incarcerated

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Deep Brain Stimulation	Behavioral Assessment	Patients receiving deep brain stimulation as a treatment will be asked to complete the behavioral task while their DBS electrode is "on" and "off".
High Intensity Focused Ultrasound	Behavioral Assessment	Patients receiving high intensity focused ultrasound as a treatment will be asked to complete the behavioral task pre and post their treatment.

Primary Outcome Measures

Name	Time	Method
Performance Error on Visuomotor Task	baseline, a week after HIFU treatment, several weeks after DBS implantation	The visuomotor task has practice, baseline, and experimental trials. Performance on the task will be compared between groups (HIFU treatment and DBS treatment) before and after treatment.

Trial Locations

Locations (1)

University of Virginia; 🇺🇸 Charlottesville, Virginia, United States