Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.

Not Applicable

• Conditions: Parkinson Disease; Dystonia; Tourette Syndrome; Parkinsonian Disorders; Movement Disorders

• Registration Number: NCT00355927
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.

Detailed Description

Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.

Study Timeline

• Study First Submitted: 2006-07-23
• Study First Submitted QC: 2006-07-23
• Study First Posted: 2006-07-25
• Status Verified: 2006-08
• Study Start: 2006-09
• Last Update Submitted: 2007-11-01
• Last Update Posted: 2007-11-02
• Study Completion: 2008-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Candidate for Deep Brain Stimulation Surgery.
• Informed concent obtained.

Exclusion Criteria

• Suspected difficult intubation (by history or physical examination).
• Allergy to Propofol, eggs or soy-beans.
• History of sleep apnea syndrome.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients	Within 24 hours needed to analyse the data

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel