Effect of subthalamic nucleus deep brain stimulation on gait and psychic function focusing on serotonergic nerve.

Not Applicable

• Conditions: Parkinson' s disease

• Registration Number: JPRN-UMIN000029958
• Lead Sponsor: Hamamatsu University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-11-20
• Last Update Posted: 17 October 2023
• Study Completion: 2025-09-11

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

1. Female patients who are pregnant or planning to become pregnant. 2. Patients with cognitive impairment, aphasia, psychiatric disorders, higher brain dysfunction, suicidal desires, antidepressant drugs. Patients who are taking antidepressant or antipsychotic medications. 3. Patients who are judged by researchers as inappropriate to participate in this study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Binding potentials of [11C]N,N dimethyl 2 (2 amino 4 cyanophenylthio)benzylamine ([11C]DASB) PET. Comparison between preoperative bindings and those of six months after surgery. Binding potentials of patients who had operated five to eight years before are also evaluated.

Secondary Outcome Measures

Name	Time	Method
[11C] 2 carbomethoxy 3b (4 fluorophenyl) tropane ( [11C] CFT) PET is also performed for the same patient, and the binding potential is evaluated in the same way.