nilateral deep brain stimulation for the treatment of drug-refractory simple partial epilepsy
Not Applicable
Recruiting
- Conditions
- focal epilepsy
- Registration Number
- RBR-4pfcg78
- Lead Sponsor
- Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Volunteers with focal motor epilepsy, sensitive, with auditory and visual symptomatology refractory to conservative treatment; age 18 to 60 years; Brazilian; with structural lesion identified by the MRI, entering primary, somesthetic, visual or auditory motor area, without other lesions.
Exclusion Criteria
Volunteers with focal epilepsy combined with other types of epilepsy; with comorbidities that make the surgical procedure high risk; active infections; uncontrolled systemic arterial hypertension; uncontrolled blood dyscrasias; use of antiplatelet or anticoagulant drugs which temporary suspension is impracticable due to potential risks; impossibility to attend follow up appointments.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The reduction or elimination of focal motor, sensory, visual, and auditory seizures through deep brain stimulation (DBS) of the ventral intermediate nucleus/ventral posterior oral (Vim/VOp), ventral posterior nucleus (VP), lateral geniculate body (GLC) and medial geniculate body (MGC), respectively, defining these specific thalamic nuclei as alternative surgical targets, or even first choice, since the risks of ECP are lower than those of surgical resections for the treatment of focal epilepsies.
- Secondary Outcome Measures
Name Time Method The improvement of the quality of life of the research participants, secondary to the reduction or elimination of convulsive crises, after the proposed surgery; and the discovery of the participation of specific thalamic nuclei (Vim/VOp, VP, GLB and MGB) pathophysiology of focal epilepsy.