Stimulation of the anterior thalamic nucleus in refractory epilepsy: Neurophysiological aspects and effects on cognitio
- Conditions
- Seizure disorder10039911
- Registration Number
- NL-OMON44832
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 28
Medically refractory epilepsy
No possibility for resective epilepsy surgery
Incapacitating epilepsy or seizures (no absolute minimal frequency)
Minimum age 18 years
Underlying malignancies, whenever life expectancy is lower than 2 years
Co-medication with anti-inflammatory drugs or systemic diseases with inflammation are possible exclusion criteria, depending on severity and stability. Whenever there is a stable disease, with a reasonable chance of sustained stability, and stable medication, inclusion is possible. In other cases, patients will be excluded.
There also may be clinical grounds on which the specialist team may decide that a patient does or does not qualify for ATN-DBS treatment. The team will be more hesitant in case of (co-existent) psychogenic, non-epileptic attacks, or low IQ (below 70).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>This observational study aims at the registration of ATN signals in the<br /><br>immediate postoperative stage.<br /><br>We compare these parameters in groups with good response and patients with poor<br /><br>response.<br /><br>Note that these parameters are (up till now) not clinically significant end<br /><br>points.</p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>