The Effect of peptide-based formula compared with isocaloric, isonitrogenous formula by early enteral feeding in critically-ill patients

Thai Otsuka Pharmaceutical Co., Ltd0 个研究点目标入组 54 人开始时间: 2022年5月7日最近更新: 2024年8月19日

研究概览

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•1.Willing to participate clinical study with signing consent form
•2.Age 15 year or above
•3.Admit on Surgical ICU ward
•4.Tend to be prescribed tube feeding in ICU at least 5 days and up to 14 days
•5.Risk of malnutrition on mild to moderate by BNT assessment
•6.BMI 18-40 kg/m2
•7.Can be assigned tube feeding within 48 hr after operation
•8.Haemodynamic stable. In case of taking norepinephrine, would take not more than 15 microgram/min or 0.3 microgram/kg/min

•1. Experiences aspiration pneumonia
•2. Experiences thyroid disease
•3. Experiences severe hepatic impairment
•4. Diagnosed to ascites
•5. Diagnosed to CKD or renal replacement therapy
•6. Diagnosed to abdominal hypertension or fluid overload
•7. Takes fentanyl more than 2 microgram per kg per hr or morphine more than 0.05 milligram per kg per hr
•8. Has parenteral nutrition administration
•9. Experiences food allergy such as Whey Protein, Casein ,
•10 Diagnosed to incurable disease that could not participate the study such as uncontrolled cancer,
•11 Experiences chemotherapy or radiotherapy within 6 months ago. (including immunosuppressor taking such as prednisolone 7 days continuously within 4 months before enrolment ,
•12 Experiences immune disorder such as HIV-positive
•13. Diagnosed to burn at severity level 2 or 3 with wound 50% of total body surface area
•14. Taking tube feeding less than 70% of total requirement

发起方