Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation

Not Applicable

• Conditions: Sports Nutritional Physiological Phenomena
• Interventions: Dietary Supplement: Maltodextrin; Dietary Supplement: Sodium bicarbonate

• Registration Number: NCT03505970
• Lead Sponsor: University of Sao Paulo

Brief Summary

The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-03-31
• Study First Submitted QC: 2018-04-13
• Study First Posted: 2018-04-23
• Status Verified: 2019-06
• Last Update Submitted: 2019-06-04
• Last Update Posted: 2019-06-06
• Study Start: 2019-08
• Primary Completion: 2020-11
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Healthy males

Exclusion Criteria

• Smokers
• Chronic disease
• Prior or current use of steroids
• Use of creatine in the last 6 months
• Use of beta-alanine in the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Maltodextrin	Individuals will ingest 0.3 g/kg maltodextrin before undergoing exercise
Sodium bicarbonate	Sodium bicarbonate	0.3 g∙kg-1body mass of sodium bicarbonate

Primary Outcome Measures

Name	Time	Method
H+ transporter activity	5 minutes Post-exercise	Change in activity of transporters related to H+

Secondary Outcome Measures

Name	Time	Method
Exercise performance	1 hour Post-supplementation	Change in 1 km cycling time-trial performance