Prediction of Outcome in Severe Preeclampsia
- Conditions
- Leiden Factor V Deficiency,PreeclampsiaDoppler ExaminationPalental Pathology
- Registration Number
- NCT03871764
- Lead Sponsor
- Cairo University
- Brief Summary
this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes
- Detailed Description
leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 100
severe preeclampsia in 3rd trimester -
Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator from diagnosis of severe preeclampsia till one week after delivery IUFD, admission to neonatal IUC
percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature within 12 wks from diagnosis of severe preeclampsia placental abruption, prematurity, IUGR
- Secondary Outcome Measures
Name Time Method