Legionnaires' Effect on Smell

Completed

• Conditions: Legionnaires' Disease
• Interventions: Other: The University of Pennsylvania Smell Identification Test (UPSIT)

• Registration Number: NCT03321786
• Lead Sponsor: University of Pennsylvania

Brief Summary

The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants. Such testing will require approximately 20-30 minutes of the participant's time. The participants will take the University of Pennsylvania Smell Identification Test (UPSIT), a scratch-and-sniff test to assess their ability to identify odors in a forced- choice format. Volunteers will also complete a questionnaire asking personal history, demographic questions, and medical history.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-06
• Study First Submitted: 2017-10-23
• Study First Submitted QC: 2017-10-23
• Study First Posted: 2017-10-26
• Primary Completion: 2024-06-15
• Study Completion: 2024-06-15
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-23
• Last Update Posted: 2024-07-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Persons of generally good health, as obtained from a screening questionnaire who are 18 years of age and older
• Both men and women of all ethnic backgrounds will be accepted.

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Exclusion Criteria

• Age less than 18
• Pregnant Women
• Persons who mental competence is limited, such as those with dementia

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Legionnaires' Disease Volunteers	The University of Pennsylvania Smell Identification Test (UPSIT)	Volunteers who have been diagnosed/survivors of Legionnaire's Disease
Healthy Volunteers	The University of Pennsylvania Smell Identification Test (UPSIT)	Volunteers who are healthy.

Primary Outcome Measures

Name	Time	Method
Score on the University of Pennsylvania Smell Identification Test	20-30 Minutes	The number of correct odor identification responses out of 40 from the standardized University of Pennsylvania Smell Identification Test.; The total number of correct responses will then be compared to standard norms of correct responses based on demographic information such as age and sex. Comparing the scores to the standard norms collected will indicate whether a volunteer is normosmic, hyposmic, or anosmic.

Secondary Outcome Measures

Name	Time	Method
Questionnaire Responses	20-30 Minutes	These are various demographic and medical history questions regarding exposure to Legionella Pneumonia and current experiences post diagnosis and treatment.

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States