Clinical Value of Molecular Genetic Analyzes in Gynecological Malignomas

Completed

• Conditions: Gynecologic Cancer

• Registration Number: NCT03194347
• Lead Sponsor: University Hospital Tuebingen

Brief Summary

The aim of the planned research project is to find out the clinical significance of molecular genetic analyzes in gynecological malignomas. In particular, it will be investigated how the knowledge of a molecular-genetic finding affects the therapeutic decision of the physician. Furthermore, genetic changes in the tumor tissue will be compared with the changes in CTCs, DTCs and cfDNA.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-05-22
• Study Start: 2017-05-29
• Study First Submitted QC: 2017-06-20
• Study First Posted: 2017-06-21
• Primary Completion: 2020-05-29
• Study Completion: 2021-12-31
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-06
• Last Update Posted: 2024-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

• Patients with a solid tumor disease
• The presence of a molecular genetic diagnosis of the tumor tissue from practice for human genetics
• Age > 18 years
• informed consent

Exclusion Criteria

• life expectancy <12 months or worse general condition (Karnofsky <70)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Influence of molecular genetic findings to the therapy decision	3years	It will be analyzed if the physicians selection of a therapy is influenced by a present molecular genetic finding. Therapy recommondation based on molecular genetic analysis will be compared with the acutal therapy decision.

Trial Locations

Locations (1)

University Women's Hospital; 🇩🇪 Tübingen, Germany