Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

Recruiting

• Conditions: Ewing Sarcoma
• Interventions: Other: clinical records review

• Registration Number: NCT06243588
• Lead Sponsor: Istituto Ortopedico Rizzoli

Brief Summary

assess whether there is a correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma.

Identification of reliable prognostic factors could help to identify high-risk patients, which may require a different treatment and follow up.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-25
• Study First Submitted: 2024-01-29
• Study First Submitted QC: 2024-01-29
• Study First Posted: 2024-02-06
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-04
• Last Update Posted: 2025-03-05
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021
• Age ≥ 2 years
• Diagnosis of Ewing Sarcoma
• Patients with available clinical and imaging data

Exclusion Criteria

• At least one inclusion criterion not met

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients	clinical records review	patients treated at Rizzoli Institute from 1991 to 2021.

Primary Outcome Measures

Name	Time	Method
Correlation	At baseline (Day 0)	Correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma.

Trial Locations

Locations (1)

IRCCS Itituto Ortopedico Rizzoli; 🇮🇹 Bologna, BO, Italy