Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Appendicular lean mass/height^2
Overview
Brief Summary
Estrogen-dominant gender-affirming hormone therapy (GAHT) is standard of care for transgender women and gender-diverse individuals and typically consists of estrogen together with anti-androgen/ testosterone therapy. Estrogen and testosterone balance influences fat and muscle mass, muscular strength and the development of sarcopenia. Sarcopenia, a condition characterized by the loss of muscular mass, strength, and function, in turn, is associated with increased mortality and adverse health outcomes. Estrogen-dominant GAHT may have deleterious effects on body composition and muscular performance that place TGD individuals at-risk for sarcopenia. As part of NCT04128488, our investigative team found that appendicular lean mass (ALM)/ height2 decreases after estrogen-based GAHT, thereby portending a higher risk for sarcopenia after GAHT. Early recognition of the changes in body composition and muscular performance leading to sarcopenia are critical, providing potential avenues to intervene and abrogate untoward downstream health effects. A promising intervention is resistance exercise, which has been shown in select populations to improve muscular mass and strength and reduce fat mass, and, thus, mitigate progression to sarcopenia in at-risk populations. For this prospective, pilot clinical trial, investigators will enroll participants who are about to be initiated on estrogen-dominant gender-affirming hormone therapy. Investigators will be randomizing participants 1:1 to either an at-home resistance exercise intervention or no exercise intervention (nutritional and exercise counseling only) for 12 weeks and assess muscle mass, strength, and function both before and after this 12-week period. The exercise intervention group will be provided with the necessary materials to complete the exercise program along with weekly virtual visits with our study team in order to learn their assigned exercises for the week. Further, survey tools will be administered to ascertain whether the resistance exercise intervention may affect gender congruence.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •≥ 18 years
- •Initiating GAHT with estradiol (oral, sublingual, patch, injection) AND androgen suppression (leuprolide, spironolactone or bicalutamide)
- •Identifies as either a transgender female/woman, gender-diverse, non-binary, gender non-confirming, gender-fluid, and/or gender-queer
- •Assigned male sex at birth
Exclusion Criteria
- •Current condition(s) which may preclude the ability to participate in a resistance exercise program (including but not limited to conditions which may significantly impair mobility and balance)
- •Current condition(s) where resistance exercise program may be contraindicated (including but not limited to decompensated heart failure, unstable ischemic heart disease, pulmonary hypertension, aortic aneurysm, moderate to severe valvopathies, and/or moderate to severe chronic respiratory insufficiency)
- •Use of testosterone therapy for \> 1 month in the last 6 months
- •Use of gender-affirming hormone therapy with androgen/testosterone suppression and/or estradiol therapy within 1 year of enrollment
- •Use of gender-affirming hormone therapy with androgen/testosterone suppression and/or estradiol therapy for \> 1 year at any time period prior to enrollment
- •History of an orchiectomy
- •Current resistance exercise (including but not limited to use of resistance bands, suspension equipment, body weight exercise, free weight exercise) of 60 minutes or greater per week
- •Enrollment in another study that the study investigators deem as potentially interfering with study participants or study endpoints
Arms & Interventions
Resistance Exercise Intervention
Participants in this arm will be randomized to a 12-week at-home resistance exercise program.
Intervention: Resistance Exercise Program (Behavioral)
Resistance Exercise Intervention
Participants in this arm will be randomized to a 12-week at-home resistance exercise program.
Intervention: Nutrition and Exercise Counseling (Behavioral)
No exercise intervention
Participants in this arm will receive educational counseling on nutrition and exercising.
Intervention: Nutrition and Exercise Counseling (Behavioral)
Outcomes
Primary Outcomes
Appendicular lean mass/height^2
Time Frame: 12 weeks
Change in appendicular lean mass/height\^2 (kg/m\^2) assessed via whole body DEXA in resistance exercise group
Gender congruence
Time Frame: 12 weeks
Change in gender congruence (utilizing the total scale score from Transgender Congruence Scale) in resistance exercise group
Secondary Outcomes
- Visceral adipose tissue mass(12 weeks)
- Visceral adipose tissue volume(12 weeks)
- Total fat mass(12 weeks)
- Total lean body mass(12 weeks)
- Muscular function(12 weeks)
- Hand-grip strength(12 weeks)
- Horizontal shoulder adduction strength(12 weeks)
- Shoulder extension strength(12 weeks)
- Elbow flexion strength(12 weeks)
- Elbow extension strength(12 weeks)
- Knee extension strength(12 weeks)
- Knee flexion strength(12 weeks)
- Hip extension strength(12 weeks)
- Resting energy expenditure(12 weeks)
- Resting metabolic rate(12 weeks)
- Respiratory quotient(12 weeks)
- Between-group change in appendicular lean body mass/ height^2(12 weeks)
- Between-group change in total visceral adipose tissue mass(12 weeks)
- Between-group change in visceral adipose tissue volume(12 weeks)
- Between-group change in total fat mass(12 weeks)
- Between-group change in total lean body mass(12 weeks)
- Between-group change in muscular function via the 5x sit to stand test(12 weeks)
- Between-group change in hand-grip strength(12 weeks)
- Between-group change in horizontal shoulder adduction strength(12 weeks)
- Bwtween-group change in shoulder extension strength(12 weeks)
- Between-group change in elbow flexion strength(12 weeks)
- Between-group change in elbow extension strength(12 weeks)
- Between-group change in knee extension strength(12 weeks)
- Between-group change in knee flexion strength(12 weeks)
- Between-group change in hip extension strength(12 weeks)
- Between-group change in resting energy expenditure(12 weeks)
- Between-group change in resting metabolic rate(12 weeks)
- Between-group change in respiratory quotient(12 weeks)
- Appearance congruence(12 weeks)
- Gender identity acceptance(12 weeks)
- Between-group change in appearance congruence(12 weeks)
- Between-group change in gender identity acceptance(12 weeks)
Investigators
Mabel Toribio
Assistant Professor
Massachusetts General Hospital