Efficacy of two doses of Intravenous Ondansetron on spinal anaesthesia induced hypotension and bradycardia in patients undergoing LSCS: A Comparative study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Incidence of hypotension SBP less than 90mmhg or morethan 20 percent decrease from baseline and bradycardia HR less than 60bpm
研究概览
简要总结
A Comparative study evaluated the efficacy of two intravenous doses of ondansetron in preventing spinal anaesthesia-induced hypotension and bradycardia in parturients undergoing elective LSCS. Ondansetron, administered before spinal anaesthesia, significantly reduced the incidence of hypotension, bradycardia, and vasopressor requirement compared to control, with no adverse maternal or neonatal effects. The higher dose showed slightly better haemodynamic stability. Ondansetron also decreased intraoperative nausea and vomiting. Thus, prophylactic ondansetron is a safe and effective measure to attenuate haemodynamic disturbances during spinal anaesthesia for caesarean section.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •1 Parturients scheduled for elective cesarean section under spinal anaesthesia 2 Aged 18 to 40 years 3 ASA physical statusII 4 Written informed consent.
排除标准
- •1 Allergy to study drugs 2 Pregnancy-induced hypertension (PIH) 3 Presence of any other comorbid conditions.
结局指标
主要结局
Incidence of hypotension SBP less than 90mmhg or morethan 20 percent decrease from baseline and bradycardia HR less than 60bpm
时间窗: Incidence of hypotension SBP less than 90mmhg or morethan 20 percent decrease from baseline and bradycardia HR less than 60bpm
次要结局
- Vasopressor requirement and incidence of shivering(From induction of spinal anaesthesia to 120 minutes)
研究者
DR Harshitha KR
Sapthagiri Institute of Medical Sciences and Research Centre