Vitamin D Supplementation in Childhood Atopic Dermatitis
Not Applicable
Completed
- Conditions
- Atopic Dermatitis
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: cholecalciferol (vitamin D)
- Registration Number
- NCT00879424
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
The goal of this clinical trial is to investigate the therapeutic role of vitamin D supplementation in a subset of patients with atopic dermatitis (AD): children with disease onset or worsening in the winter. The investigators hypothesis is that (1) vitamin D supplementation in patients with either wintertime onset or exacerbation of AD will improve Eczema Area and Severity Index (EASI) scores, and (2) vitamin D supplementation will improve the Investigator's Global Assessment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
Inclusion Criteria
- Age 2-17 years
- AD rated 10-72 by EASI scale
- Wintertime onset or exacerbation of AD
Exclusion Criteria
- Active skin infection
- History of summertime onset or exacerbation of AD
- History of underlying illness causing immunosuppression within the past 2 years (eg. hematologic malignancies)
- Medications causing iatrogenic immunosuppression (eg. cyclosporine; azathioprine, oral steroids) taken within the past month
- Parathyroid disease
- Acute or chronic renal disease
- Hypercalcemia or hypocalcemia
- Thyroid disease
- History of osteomalacia or Paget's disease of bone
- History of malabsorption (eg cystic fibrosis)
- Planned trip to sunny climate during the one-month study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Placebo - 1 cholecalciferol (vitamin D) -
- Primary Outcome Measures
Name Time Method Investigator Global Assessment (IGA) 1 month EASI score 1 month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Dermatology Center
🇲🇳Ulaan Baatar, Mongolia