Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer

Phase 2

Recruiting

• Conditions: Urothelial Carcinoma
• Interventions: Drug: Avelumab

• Registration Number: NCT05600127
• Lead Sponsor: Erasmus Medical Center

Brief Summary

Patients with locally advanced or clinically node positive urothelial carcinoma treated with chemotherapy, will receive 3 cycles of avelumab, followed by radical surgery.

Detailed Description

Patients with locally advanced or clinically node positive urothelial carcinoma of the bladder, ureter or urethra (cT4NxM0 or cTxN1-N3M0) with at least stable disease after treatment with 3-4 cycles of platinum-based chemotherapy, will be treated with 3 cycles of avelumab (anti-PD-L1). If there are no signs of disease progression after avelumab treatment, radical surgery of the primary tumor and a pelvic lymph node dissection will follow.

Study Timeline

• Study First Submitted: 2022-10-26
• Study First Submitted QC: 2022-10-26
• Study First Posted: 2022-10-31
• Study Start: 2022-12-01
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-06
• Last Update Posted: 2023-09-08
• Primary Completion: 2025-04
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Age ≥ 18 years.

2. Have histologically confirmed urothelial carcinoma of the bladder, upper urinary tract or urethra; a maximum of 50% of aberrant histology is allowed.

3. Have clinical stage cT4NxM0 or cTxN1-N3M0 as assessed by bimanual examination under anaesthesia, CT scan, MRI scan or PET-CT scan.

4. Have at least stable disease after a minimum of 3 or a maximum of 4 cycles of induction chemotherapy with cisplatin / carboplatin + gemcitabine according to RECIST v1.1.

5. Are fit and willing to undergo radical surgery with removal of lymph node template including all affected lymph nodes and the primary tumor.

6. World Health Organisation performance status of 0-2.

7. Provide written informed consent.

8. Negative pregnancy test in women with childbearing potential.

9. Adequate bone marrow function, including:

   1. Absolute neutrophil count (ANC) ≥1,500/mm3 or 1.5 x 109/L;
   2. Platelets ≥100 x 109/L;
   3. Hemoglobin ≥5.6 mmol/L (may have been transfused).

10. Adequate renal function, defined as estimated creatinine clearance ≥30 mL/min as calculated by the CKD-EPI eGFR.

11. Adequate liver function, including:

    1. Total serum bilirubin <1.5 x upper limit of normal (ULN);
    2. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <2.5 x ULN.

Exclusion Criteria

1. Predominant (>50%) non-urothelial carcinoma histology in the diagnostic endoresection specimen of the bladder, urethra or upper urinary tract.

2. Any test for hepatitis B virus (HBV) or hepatitis C virus (HCV) indicating acute or chronic infection.

3. Have an estimated creatinin clearance as assessed by the CKD-EPI eGFR of <30 ml/min.

4. Prior exposure to immune-mediated therapy with exclusion of Bacillus-Calmette Guérin intravesical instillations, including but not limited to other anti-CTLA-4, anti PD-1, anti PD-L1, or anti-PD-L2 antibodies.

5. Persisting toxicity related to prior chemotherapy (Grade >2 NCI CTCAE v5.0).

6. A diagnosis of any other malignancy within 2 years prior to inclusion, except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the breast or of the cervix, low grade prostate cancer on surveillance without any plans for treatment intervention, or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease.

7. ≤2 cycles of induction platinum-based chemotherapy received.

8. Progression of disease during or following induction platinum-based chemotherapy, as assessed by RECIST v1.1.

9. Distant metastatic disease.

10. Previous pelvic radiation therapy.

11. Breastfeeding women.

12. Bilateral upper urinary tract urothelial carcinoma.

13. Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible.

14. Any of the following in the previous 6 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism.

15. Active infection requiring systemic therapy.

16. Known severe hypersensitivity reactions to monoclonal antibodies (Grade 3), any history of anaphylaxis, or uncontrolled asthma (ie, 3 or more features of asthma symptom control per the Global Initiative for Asthma 2015).

17. Known prior or suspected hypersensitivity to avelumab.

18. Current use of immunosuppressive medication, EXCEPT the following:

    1. Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra-articular injection);
    2. Systemic corticosteroids at (equivalent) doses of maximum 10 mg prednisone;
    3. Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication).

19. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy, or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness.

20. Vaccination within 4 weeks of the first dose of study treatment and while on trial is prohibited except for administration of inactivate vaccines (for example, inactivated influenza vaccines) or mRNA vaccines (for example, COVID-19 vaccines).

21. Other severe acute or chronic medical conditions including colitis, inflammatory bowel disease, and pneumonitis; psychiatric condition including recent (within the past year) or active suicidal ideation or behaviour; or laboratory abnormality that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Avelumab	Avelumab	3 cycles of avelumab (Bavencio), 800mg intravenous instillation in 60 min, every 2 weeks.

Primary Outcome Measures

Name	Time	Method
Pathological complete response rate	About 1 month after radical surgery	the proportion of patients without residual UC in the surgical resection specimen, ypT0N0 (carcinoma situ is allowed), in the intention-to-treat analysis.

Secondary Outcome Measures

Name	Time	Method
Delay in surgery	About 1 month after radical surgery	The proportion of patients in whom radical surgery is delayed \>8 weeks after last administration of avelumab due to toxicity.
Survival	24 months after radical surgery	Progression-free, cancer-specific and overall survival at 24 months, calculated from the time of 1st administration of avelumab
Surgical complications	90 days after radical surgery	Assesed by Clavien-Dindo classification within 30 and 90 days from date of surgery
Non-invasive urothelial cancer	About 1 month after radical surgery	The rate of non-invasive urothelial cancer in the surgical resection specimen, stage ypT0N0/ypTisN0/ypTaN0/ypT1N0
Adverse events	90 days after administration of the last cycle of avelumab	Adverse events of assessed by the CTCAE v5.0

Trial Locations

Locations (4)

Amphia ziekenhuis; 🇳🇱 Breda, Brabant, Netherlands

Jeroen Bosch ziekenhuis; 🇳🇱 Den Bosch, Brabant, Netherlands

Erasmus MC; 🇳🇱 Rotterdam, Zuid Holland, Netherlands

Radboud UMC; 🇳🇱 Nijmegen, Gelderland, Netherlands