Expanding Autism Diagnostic Biomarkers to Kenya
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Autism
- Sponsor
- Indiana University
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Agreement between eye-tracking biomarker score and autism diagnosis
- Status
- Completed
- Last Updated
- 6 months ago
Overview
Brief Summary
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
Detailed Description
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series (less than 15 mins) of eye-tracking measures (e.g., looking time, pupil diameter, oculomotor dynamics), which may be associated with autism in young children. The investigators will recruit children from Moi Teaching and Referral Hospital (MTRH; Eldoret, Kenya) previously enrolled in the Health Equity Advancing through Learning Health Systems Research (HEAL-R) Autism at MTRH study (IREC/664/2023, approval number 0004633)
Investigators
Rebecca McNally Keehn
Assistant Professor of Pediatrics
Indiana University
Eligibility Criteria
Inclusion Criteria
- •Children enrolled in the HEAL-R Autism at MTRH study
- •Children ages 14-72 months
- •Caregivers of children must speak Kiswahili (local language) or English.
Exclusion Criteria
- •Children not enrolled in the HEAL-R Autism at MTRH study
- •Children younger than 14 months or older than 72 months
- •Caregivers of children do not speak Kiswahili (local language) or English.
Outcomes
Primary Outcomes
Agreement between eye-tracking biomarker score and autism diagnosis
Time Frame: Day 1
Group (autism presence/absence) differences in the composite eye-tracking biomarker score, a consolidated measure based on eye-tracking indices, will be tested to determine whether this metric is predictive of autism diagnosis. Clinical diagnosis was obtained based upon a standardized clinical evaluation in the parent study. The evaluation included: 1) a semi-structured caregiver(s) clinical interview to gather information about developmental history and autism symptoms and 2) a battery of standardized child clinical observational measures. Eye-tracking biomarkers will be recorded during a brief one-time research visit.