Use of Eye Tracking to Aid in Autism Risk Detection
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Indiana University
- Enrollment
- 100
- Locations
- 2
- Primary Endpoint
- Agreement between eye-tracking biomarker score and diagnosis
Study Overview
Brief Summary
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
Detailed Description
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series (less than 15 mins) of eye-tracking measures (e.g., looking time, pupil diameter, oculomotor dynamics), which may be associated with autism in young children ages 12-48 months. We will recruit children from Riley Hospital for Children at Indiana University Health clinics to determine whether these measures may help determine autism risk.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 12 Months to 48 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Young children ages 12-48 months scheduled for health care visits at Riley Hospital for Children at Indiana University Health clinics (e.g., Pediatric Care Center clinics).
- •Children must have English- or Spanish-speaking caregivers.
- •Children must have a legal guardian that is able to provide consent.
Exclusion Criteria
- •Child is younger than 12 months or older than 48 months.
- •Child's caregiver(s) is not English- or Spanish-speaking.
Arms & Interventions
Children Undergoing Developmental Evaluation
Children undergoing a standard of care developmental evaluation will be enrolled into the study. After the completion of the developmental evaluation, research participation includes a one-time eye-tracking activity in which the child will view a series of different pictures and movies while their eye movements are tracked and recorded.
Intervention: Eyelink Portable Duo (Diagnostic Test)
Outcomes
Primary Outcomes
Agreement between eye-tracking biomarker score and diagnosis
Time Frame: Day 1
The composite eye-tracking biomarker score, a consolidated measure based on eye-tracking indices that predict autism outcome, will be compared to the categorical autism diagnosis (autism presence/absence). Clinical diagnosis is obtained based upon a standard clinical evaluation conducted by an expert clinical psychologist. The evaluation will include 1) a semi-structured caregiver(s) clinical interview to gather information about developmental history and autism symptoms and 2) a battery of standardized child clinical observational measures. The evaluation will be conducted over a one-time 2-hour clinical autism evaluation. Eye-tracking will be recorded immediately following the clinical evaluation for a period of up to 15 minutes.
Secondary Outcomes
No secondary outcomes reported
Investigators
Rebecca McNally Keehn
Assistant Professor of Pediatrics
Indiana University