Use of Eye Tracking to Aid in Autism Risk Detection
Overview
- Phase
- Not Applicable
- Intervention
- Eyelink Portable Duo
- Conditions
- Autism
- Sponsor
- Indiana University
- Enrollment
- 100
- Locations
- 2
- Primary Endpoint
- Agreement between eye-tracking biomarker score and diagnosis
- Status
- Recruiting
- Last Updated
- 10 days ago
Overview
Brief Summary
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
Detailed Description
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series (less than 15 mins) of eye-tracking measures (e.g., looking time, pupil diameter, oculomotor dynamics), which may be associated with autism in young children ages 12-48 months. We will recruit children from Riley Hospital for Children at Indiana University Health clinics to determine whether these measures may help determine autism risk.
Investigators
Rebecca McNally Keehn
Assistant Professor of Pediatrics
Indiana University
Eligibility Criteria
Inclusion Criteria
- •Young children ages 12-48 months scheduled for health care visits at Riley Hospital for Children at Indiana University Health clinics (e.g., Pediatric Care Center clinics).
- •Children must have English- or Spanish-speaking caregivers.
- •Children must have a legal guardian that is able to provide consent.
Exclusion Criteria
- •Child is younger than 12 months or older than 48 months.
- •Child's caregiver(s) is not English- or Spanish-speaking.
Arms & Interventions
Children Undergoing Developmental Evaluation
Children undergoing a standard of care developmental evaluation will be enrolled into the study. After the completion of the developmental evaluation, research participation includes a one-time eye-tracking activity in which the child will view a series of different pictures and movies while their eye movements are tracked and recorded.
Intervention: Eyelink Portable Duo
Outcomes
Primary Outcomes
Agreement between eye-tracking biomarker score and diagnosis
Time Frame: Day 1
The composite eye-tracking biomarker score, a consolidated measure based on eye-tracking indices that predict autism outcome, will be compared to the categorical autism diagnosis (autism presence/absence). Clinical diagnosis is obtained based upon a standard clinical evaluation conducted by an expert clinical psychologist. The evaluation will include 1) a semi-structured caregiver(s) clinical interview to gather information about developmental history and autism symptoms and 2) a battery of standardized child clinical observational measures. The evaluation will be conducted over a one-time 2-hour clinical autism evaluation. Eye-tracking will be recorded immediately following the clinical evaluation for a period of up to 15 minutes.