Perioperative Protective Effects of Lidocaine
Phase 2
Terminated
- Conditions
- Elective Surgical ProcedureColorectal Surgery
- Interventions
- Drug: NaCl 0,9%
- Registration Number
- NCT00413127
- Lead Sponsor
- University Hospital Muenster
- Brief Summary
The purpose of this study is to comparing effects of intravenously (IV) administered lidocaine to effects of epidurally (ED) administered lidocaine in patients undergoing elective colorectal surgery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 78
Inclusion Criteria
- elective colorectal surgery
Exclusion Criteria
- ASA > 3
- history of anti-inflammatory therapy
- history of inflammatory bowl diseases
- history of chronic pain treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3 lidocaine intraoperatively lidocaine i.v. postoperatively lidocaine epidural 4 lidocaine lidocaine epidural 5 NaCl 0,9% placebo i.v. 1 lidocaine Lidocaine i.v 2 lidocaine intraoperatively lidocaine epidural postoperatively lidocaine i.v.
- Primary Outcome Measures
Name Time Method length of postoperative hospital stay end of hospital stay
- Secondary Outcome Measures
Name Time Method Postoperative Analgesia until end of hospital stay Hyperalgesia perioperative postoperative day 2, 4, 8, end of hospital stay and follow-up Cytokine levels perioperative before surgery and 4 hours, 2 and 4 days after surgery Bowel motility perioperative days after surgery Length of PACU stay end of PACU stay Cognitive function perioperatively before surgery, one and four days after surgery, at end of hospital stay and follow-up Incidence of wound healing disturbances within 4 weeks after surgery
Trial Locations
- Locations (3)
University Hospital Muenster
🇩🇪Muenster, Germany
St. Franziskushospital Muenster
🇩🇪Muenster, Germany
St. Marienhospital
🇩🇪Vechta, Germany