Steroïde hormonen en eaLocal steroid production (intracrinology) in endometriosis – inter & intra patient variabilityndometriose
Not Applicable
- Conditions
- <p>endometriosis local estrogen metabolism intracrinology</p>10046828
- Registration Number
- NL-OMON20678
- Lead Sponsor
- Maastricht University Medical Centre (azM)
- Brief Summary
non applicable
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 400
Inclusion Criteria
Cases:
- Being older than 18 year
Exclusion Criteria
Cases:
- Being younger than 18 year
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Clinical data (via a case report form) and epidemiological, life style and symptoms data (via a questionnaire) will be collected prospectively. Blood samples will be taken before treatment. During surgery endometrial and endometriosis biopsies will be collected. Serum and tissue will be analysed for the steroid profile (LCMS). Biopsies will be assessed for the levels of the enzymes involved in the local estrogen generation. Steroid metabolism data will be correlated with clinical characteristics and symptomatology in each subject.</p><br>
- Secondary Outcome Measures
Name Time Method <p>non applicable</p><br>