ocal steroid production (intracrinology) in endometriosis - inter & intra patient variability

Recruiting

Conditions: 10016417
endometriosis

Registration Number: NL-OMON55550

Lead Sponsor: niversitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 400

Inclusion Criteria

Cases:
- Being older than 18 year
- Diagnosis of endometriosis (laparoscopically confirmed)
- Being scheduled for elective laparoscopic (or laparotomy) surgery for
endometriosis
- Not taking hormonal medications in the previous three months
- Subjects must have signed an approved informed consent, Controls:
- Being older than 18 year
- Being premenopausal
- Having no prior diagnosis of endometriosis
- Not taking hormonal medications in the previous three months
- Being scheduled for any gynaecological surgery like for tubal ligation, for a
benign uterine disease, for diagnosis, for laparoscopic hysterectomy and
bilateral adnexectomy
- Subjects must have signed an approved informed consent

Exclusion Criteria

Cases:
- Being younger than 18 year
- Diagnosis of atypical hyperplasia, other types of cancer
- Previous diagnosis of endometrial carcinoma
- Being under hormonal medication during the three months preceding the sampling
- Pregnancy
- Inability to approve the informed consent form, Controls:
- Being younger than 18 year
- Being diagnosed with a benign ovarian diseases
- Being diagnosed with any malignancy
- Previous diagnosis of endometriosis
- Being under hormonal medication during the three months preceding the sampling
- Pregnancy
- Inability to approve the informed consent form

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Clinical data (via a case report form) and epidemiological data (via a<br /><br>questionnaire) and urine will be collected prospectively. Blood samples will be<br /><br>taken before treatment. During surgery endometrial, endometriosis and<br /><br>peritoneal biopsies will be collected. Serum and tissue will be analysed for<br /><br>the steroid profile (LCMS). Biopsies will be assessed for the levels of the<br /><br>enzymes involved in the local estrogen generation</p><br>

Secondary Outcome Measures