Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes - rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene in Patellar Instability in Children.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Patients with recurrent patellar dislocation
研究概览
简要总结
The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.
详细描述
After being informed about the study and potential risk all of participants were performed phisical examination and genetic test. In the study we established two groups: In first group- 50 patients with recurrent patellar dislocation and without any genetic disorders. In the second one 200 patients without recurrent patellar dislocation and genetic disorders. All pediatric patients were between 7 and 17 years old in two groups respectivly.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •First-time diagnosed or recurrent patellar dislocation patient from 7 to 17 age years old.
排除标准
- •Patient's age under
- •Presence of genetic diseases such as: Down's syndrome or Marfan's syndrome.
- •Metabolic disorders.
- •Previous knee surgeries.
- •Cartilage and bone fractures in the knee.
- •No consent for examination from the legal guardian.
结局指标
主要结局
Patients with recurrent patellar dislocation
时间窗: 2022-2023
Patients with recurrent patellar dislocation
Control group without obvious joint hipermobility
时间窗: 2022-2023
Control group without obvious joint hipermobility
次要结局
未报告次要终点