Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Not Applicable

Completed

• Conditions: Surgery
• Interventions: Drug: Propofol; Drug: Sevoflurane

• Registration Number: NCT03263078
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

The purpose of this study is to compare the difference between total intravenous anesthesia to inhaled anesthesia in free flap surgery.

Detailed Description

The aim of this study is to perform a randomized controlled trial to examine the effects of different anesthetics on intraoperative hemodynamic stability during free flap surgery and postoperative complications

Study Timeline

• Study First Submitted: 2017-08-21
• Study First Submitted QC: 2017-08-25
• Study First Posted: 2017-08-28
• Study Start: 2017-10-01
• Primary Completion: 2019-10-30
• Study Completion: 2019-12-31
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-28
• Last Update Posted: 2022-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TIVA with Propofol in free flap surgery	Propofol	Total intravenous anesthesia(TIVA) with Propofol
Sevoflurane in free flap surgery	Sevoflurane	Inhalation anesthesia with Sevoflurane

Primary Outcome Measures

Name	Time	Method
Number of patients with postoperative pulmonary complication	1 day	A radiologist who was unaware of the group assignment evaluated the images and confirmed any PPCs, such as pulmonary edema, pneumonia, pleural effusion or atelectasis

Secondary Outcome Measures

Name	Time	Method
Mean arterial blood pressure, MAP (mmHg)	1 day	Measure MAP hourly (T0: First data after monitor instrumentation, T1: first hour, T2: second hour, Tend: at the end of surgery) and compare the difference between groups)
Cardiac index , CI (L·min-1·m-2))	1 day	Measure CI hourly (T0: First data after monitor instrumentation, T1: first hour, T2: second hour, Tend: at the end of surgery) and compare the difference between groups)
Systemic vascular resistance index, SVRI (dynes · sec · cm-5)	1 day	Measure SVRI hourly (T0: First data after monitor instrumentation, T1: first hour, T2: second hour, Tend: at the end of surgery) and compare the difference between groups)
Stroke Volume Variation , SVV (%)	1 day	Measure SVV hourly (T0: First data after monitor instrumentation, T1: first hour, T2: second hour, Tend: at the end of surgery) and compare the difference between groups)

Trial Locations

Locations (1)

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwain, Taiwan