Early detection of chronic obstructive pulmonary disease (COPD) using a novel technique for assessing lung unevenness (inhomogeneity)
Not Applicable
- Conditions
- Chronic obstructive pulmonary diseaseRespiratory
- Registration Number
- ISRCTN46851791
- Lead Sponsor
- niversity of Oxford
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
1. Age 25-60 years
2. Current smokers with >10 pack years smoking history (Not applicable for the control group who are non-smokers)
Exclusion Criteria
1. Current diagnosis of respiratory disease
2. Pregnancy
3. Significant cardiovascular disease e.g. heart failure
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ung heterogeneity indices: slnCL (standard deviation of alveolar compliance distribution across lung volume), sVD (standard deviation of deadspace distribution across lung volume), VD (total anatomical deadspace), and VD/FRC (ratio of total deadspace to functional residual capacity) measured using the novel technique at the Research Visit in chronic current smokers (tobacco smokers of >= 10 pack-years) with non-obstructive spirometry vs non-smoker healthy controls
- Secondary Outcome Measures
Name Time Method <br> 1. Effect of participant pack years of smoking measured using smoking history data within questionnaires obtained at the Research Visit on the lung heterogeneity parameters.<br> 2. Other potential markers of disease in smokers, e.g. markers of inflammation in blood (eosinophil count, CRP), exhaled nitric oxide and symptoms scores measured at the Research Visit and their correlation with the novel lung heterogeneity indices.<br> 3. Other lung function measures: FEV1 % predicted , FEV1/FVC, FEF25-75%, measured with spirometry, and R5-R20, measured with impulse oscillometry at the Research Visit and their correlation with the novel heterogeneity indices.<br>