Effects of Exogenous Ketones in Healthy Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Blood health parameters
研究概览
简要总结
Exogenous ketone supplements in the form of beta-hydroxybutyrate can be utilized as an alternate energy source (in place of glucose) for all cells except red blood cells. Exogenous ketone administration has been shown to be beneficial in terms of reducing oxidative stress, improving neuronal energy supplies, and maintaining normal blood glucose levels. The purpose of this study is to determine the effects and safety of supplementing with exogenous ketones for 6-weeks in healthy college-aged males and females. The results of this proposed study will determine whether exogenous ketone supplementation can be useful in promoting better body composition, energy levels, and blood cholesterol, glucose, and insulin levels.
详细描述
A total of 22 subjects, male and female, were randomized to either a ketone salt group or a placebo group. Both the participants and investigators were blinded, as the supplements were coded by an external lab. Data was collected at baseline and again in 6-weeks. Participants consumed 2 servings of the assigned supplement daily for 6 weeks. Measures included body composition, blood pressure, questionnaires, blood work (comprehensive metabolic panel, complete blood count, and lipid panel), and a urinalysis. Also, blood ketone levels were assessed before and periodically after consuming the supplemental drink (30 and 60 minutes post drink). These measures were performed at both baseline and 6-weeks later.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Participant, Investigator)
盲法说明
Supplemental packets were not labeled except with the code A or B - placed by the supplement laboratory. PI notified of groups after completion.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy (no known conditions)
排除标准
- •Chronic smoker Pregnant
结局指标
主要结局
Blood health parameters
时间窗: 6 weeks on the supplement
Comprehensive Metabolic Panel
Blood ketone levels
时间窗: Baseline and 6 weeks after chronic consumption
Blood ketones assessed 30- and 60 minutes after consuming the supplement
Body Composition
时间窗: 6 weeks on the supplement
Skinfold measure
Cardiovascular
时间窗: 6 weeks on the supplement
Blood Pressure
Blood health parameter
时间窗: 6 weeks on the supplement
Complete blood count
次要结局
未报告次要终点
研究者
Angelia Holland
Assistant Professor
Augusta University